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Biology
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What is one reason bigger animals tend to live longer than smaller ones?1 / 9
Larger bodies often have slower metabolisms, so their cells wear out more slowly over time. A whale's giant body ages far more slowly than a mouse's tiny one.
Neurobiology: The Action Potential and Synaptic Transmission Neurons communicate using two linked electrical and chemical processes. Within a single neuron, information travels as an action potential — a stereotyped, self-propagating change
Biology
Neurobiology: The Action Potential and Synaptic Transmission
What are the three macronutrients, and what do they have in common?1 / 10
Carbohydrates, proteins, and fats. All three are nutrients the body needs in relatively large amounts, and all three can be broken down to release energy, measured in kilocalories (kcal).
In a rod photoreceptor, absorption of a photon by rhodopsin ultimately leads to which immediate change at the plasma membrane?
AOpening of additional cGMP-gated channels, causing further depolarizationBClosure of cGMP-gated channels as cGMP is hydrolyzed by PDE, causing hyperpolarizationCDirect opening of a ligand-gated ion channel by retinal itselfDActivation of voltage-gated Na+ channels, generating an action potential in the outer segment
Mitosis is the basic process by which one cell divides to make two new cells that are identical to each other and to the original cell. It is how your body grows and repairs itself.
Biology
Biology · L2 · The Simple Steps of Cell Division (Mitosis)
Describe the physical principle by which optical tweezers trap and manipulate a micron-scale bead attached to a single biomolecule, and how this enables force-extension measurements.1 / 9
Optical tweezers use a tightly focused laser beam to trap a dielectric (typically polystyrene or silica) microsphere near the beam's focal point: the steep intensity gradient near the focus creates a gradient force pulling the higher-refractive-index bead toward the region of highest light intensity, while scattering force pushes it slightly along the beam axis, together producing a stable three-dimensional trap whose effective stiffness (typically approximated as a linear, Hookean restoring force for small displacements) can be precisely calibrated.
Biology
Biology · L5 · Biophysics and Single-Molecule Methods
Phylogenetics and Cladistics Phylogenetics reconstructs the evolutionary relationships among organisms and represents them as branching trees. Cladistics, the dominant modern framework, insists that classification should reflect only geneal
According to the acid growth hypothesis, auxin promotes cell elongation by:
ADirectly increasing turgor pressure inside the cellBActivating H+-ATPases that acidify the cell wall, activating expansins that loosen the wallCIncreasing chlorophyll synthesisDBlocking water uptake by the cell
Besides giving skin its color, what is one important job melanin does?1 / 9
Melanin helps protect skin from the sun. It absorbs and scatters ultraviolet (UV) radiation from sunlight, which reduces the damage UV rays can do to skin cells.
Biology
Biology · L2 · Melanin: Sun Protection and Inheritance
Food preservation means treating or storing food in ways that slow down or stop the growth of the microorganisms that cause it to spoil, so the food stays safe to eat for longer.
Biology
Biology · L2 · Why Food Spoils and How We Slow It Down
What are the four broad mechanistic categories of antibiotic resistance?1 / 10
(1) Enzymatic inactivation of the drug, (2) modification of the drug's target so it no longer binds, (3) reduced uptake or increased efflux of the drug, and (4) bypass — acquiring an alternative pathway or enzyme that performs the same function but is insensitive to the drug.
An alternative version of a gene. Alleles occupy the same location (locus) on homologous chromosomes and can produce different versions of the same trait, such as purple or white flower color.
What types of DNA damage does base excision repair (BER) correct, and what is its overall mechanism?1 / 11
BER corrects small, non-helix-distorting base lesions such as deamination (e.g. cytosine to uracil), oxidation (e.g. 8-oxoguanine), and alkylation damage. A DNA glycosylase specific to the damaged base recognizes and flips it out of the double helix, cleaving the glycosidic bond to remove just the damaged base and leave an abasic (AP) site. AP endonuclease then nicks the DNA backbone at that site, DNA polymerase β fills the single-nucleotide gap using the intact complementary strand as a template, and DNA ligase seals the remaining nick.
What are the six original hallmarks of cancer proposed by Hanahan and Weinberg (2000), and what two enabling characteristics were later added?1 / 9
The 2011 update added genome instability and mutability, and tumor-promoting inflammation as enabling characteristics that accelerate acquisition of the core hallmarks, plus deregulated cellular energetics (the Warburg effect) and evading immune destruction as emerging hallmarks.