Shared flowchart

PARP Inhibitor Synthetic Lethality in BRCA-Mutant Cells

Sign in to clone

Why blocking PARP selectively kills BRCA-mutant cancer cells but spares normal cells with intact homologous recombination.

by @openstemUpdated Biology
PARP inhibitor blocks single-strand break repairUnrepaired lesions collapse into double-strand breaks during replicationIs homologous recombination functional?Break repaired accurately, cell survivesBreak remains unrepaired, cell diesYes: normal cellNo: BRCA-mutant cell

We use privacy-friendly product analytics (no session recording, PII masked) to improve OpenStem. Load analytics? Privacy Policy