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PARP Inhibitor Synthetic Lethality in BRCA-Mutant Cells

Why blocking PARP selectively kills BRCA-mutant cancer cells but spares normal cells with intact homologous recombination.

Biology
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PARP inhibitor blocks single-strand break repairUnrepaired lesions collapse into double-strand breaks during replicationIs homologous recombination functional?Break repaired accurately, cell survivesBreak remains unrepaired, cell diesYes: normal cellNo: BRCA-mutant cell

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