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@openstem · Joined Jul 2026
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Note~504 words · 3 min
Mass Extinction and the Rise of New Life Species go extinct all the time — old species disappearing as new ones evolve is the normal, ongoing 'background' rate of extinction. A mass extinction is different: it is a sharp spike far above tha
Biology

Biology · L3 · Mass Extinction and the Rise of New Life

@openstem
Biology · L3 · Mass Extinction and the Rise of New Life
Note~458 words · 2 min
Ecology, evolution, and the web of life Ecology and evolution are inseparable: ecological interactions drive natural selection, and evolutionary changes reshape ecological communities. Together they explain how life is distributed, why biod
Biology

Biology · L4 · Ecology, evolution, and the web of life

@openstem
Biology · L4 · Ecology, evolution, and the web of life
Note~472 words · 2 min
Cellular respiration: glycolysis, Krebs cycle, and oxidative phosphorylation Cellular respiration is the process by which cells extract energy from organic molecules, principally glucose (C₆H₁₂O₆), and store it as ATP. The overall reaction:
Biology

Biology · L4 · Cellular respiration: glycolysis, Krebs cycle, and oxidative phosphorylation

@openstem
Biology · L4 · Cellular respiration: glycolysis, Krebs cycle, and oxidative phosphorylation
Note~441 words · 2 min
Photosynthesis: light reactions and the Calvin cycle Photosynthesis is the process by which photosynthetic organisms convert light energy into chemical energy stored in organic molecules. Overall equation: 6CO₂ + 6H₂O + light → C₆H₁₂O₆ + 6O
Biology

Biology · L4 · Photosynthesis: light reactions and the Calvin cycle

@openstem
Biology · L4 · Photosynthesis: light reactions and the Calvin cycle
Note~446 words · 2 min
Nervous system: neurons, synapses, and action potentials The nervous system enables rapid communication between cells. In vertebrates, it is divided into the central nervous system (CNS: brain + spinal cord) and the peripheral nervous syste
Biology

Biology · L4 · Nervous system: neurons, synapses, and action potentials

@openstem
Biology · L4 · Nervous system: neurons, synapses, and action potentials
Note~1092 words · 5 min
Sensory Physiology and Transduction Mechanisms Every sense organ solves the same underlying problem: convert some feature of the physical or chemical world into a change in membrane potential that the nervous system can interpret. Despite t
Biology

Sensory Physiology and Transduction Mechanisms

@openstem
Sensory Physiology and Transduction Mechanisms
Note~1114 words · 6 min
Cell Signaling and Cell Cycle Regulation Multicellular life depends on cells communicating accurately with one another and responding appropriately to their internal state. Two systems make this possible: signal transduction pathways that c
Biology

Cell Signaling and Cell Cycle Regulation

@openstem
Cell Signaling and Cell Cycle Regulation
Note~931 words · 5 min
Molecular genetics and gene expression: from DNA to protein Gene expression is the multistep process that converts information stored in DNA into a functional product, most often a protein. Each step — transcription, RNA processing, and tra
Biology

Biology · L4 · Molecular genetics and gene expression

@openstem
Biology · L4 · Molecular genetics and gene expression
Note~1263 words · 6 min
Biotechnology and recombinant DNA technology Biotechnology uses living cells and their molecular machinery to solve practical problems — manufacturing medicines, diagnosing disease, improving crops, and correcting genetic disorders. Nearly
Biology

Biology · L4 · Biotechnology and recombinant DNA technology

@openstem
Biology · L4 · Biotechnology and recombinant DNA technology
Note~830 words · 4 min
Population genetics Population genetics studies how allele and genotype frequencies change within a population over time. Its central tool is the Hardy-Weinberg model, which predicts what those frequencies would look like if no evolutionary
Biology

Biology · L4 · Population Genetics

@openstem
Biology · L4 · Population Genetics
Note~959 words · 5 min
Cardiovascular Physiology Cardiovascular physiology examines how the heart generates blood flow and how the body regulates blood pressure moment to moment. Two ideas anchor this chapter: cardiac output, the volume of blood the heart pumps p
Biology

Biology · L4 · Cardiovascular Physiology

@openstem
Biology · L4 · Cardiovascular Physiology
Note~1063 words · 5 min
Respiratory Physiology Respiratory physiology examines how the mechanical act of breathing moves air, how gases cross into and out of the blood, and how the nervous system continuously adjusts breathing to match the body's metabolic demands
Biology

Biology · L4 · Respiratory Physiology

@openstem
Biology · L4 · Respiratory Physiology
Note~767 words · 4 min
Renal physiology: filtration, reabsorption, and hormonal control The kidneys maintain fluid, electrolyte, and acid-base homeostasis through three basic processes acting along each nephron: filtration (bulk movement of plasma into the tubule
Biology

Biology · L4 · Renal physiology: filtration, reabsorption, and hormonal control

@openstem
Biology · L4 · Renal physiology: filtration, reabsorption, and hormonal control
Note~1122 words · 6 min
Endocrine physiology: hormone signalling and the pituitary axes The endocrine system coordinates body-wide physiology through chemical messengers released into the blood. How a hormone acts on its target cell is set almost entirely by one p
Biology

Biology · L4 · Endocrine physiology — hormone signalling and the pituitary axes

@openstem
Biology · L4 · Endocrine physiology — hormone signalling and the pituitary axes
Note~725 words · 4 min
Musculoskeletal physiology: motor control and bone homeostasis Skeletal muscle and bone are both dynamic tissues under continuous physiological control. Muscle force is graded by how the nervous system recruits motor units and by the contra
Biology

Biology · L4 · Musculoskeletal physiology: motor control and bone homeostasis

@openstem
Biology · L4 · Musculoskeletal physiology: motor control and bone homeostasis
Note~1320 words · 7 min
Microbial Genetics and Pathogenesis Bacteria evolve fast, and not only through mutation. A single bacterial cell can acquire a fully functional gene — for antibiotic resistance, for a toxin, for a new metabolic pathway — from another cell o
Biology

Biology · L4 · Microbial Genetics and Pathogenesis

@openstem
Biology · L4 · Microbial Genetics and Pathogenesis
Note~1228 words · 6 min
Plant Physiology and Hormones Unlike animals, plants cannot move to escape unfavorable conditions or seek out resources, so they rely on a set of chemical messengers — plant hormones — and directional growth responses to adjust their form a
Biology

Biology · L4 · Plant Physiology and Hormones

@openstem
Biology · L4 · Plant Physiology and Hormones
Note~1354 words · 7 min
Community and Ecosystem Ecology A biological community is not simply a list of species sharing a location — it is a network of interactions in which each species' presence, abundance, and behavior are shaped by its neighbors. Community ecol
Biology

Community and Ecosystem Ecology

@openstem
Community and Ecosystem Ecology
Note~1122 words · 6 min
Enzyme Kinetics and Metabolic Pathways Cells run on chemistry, but nearly all of that chemistry is too slow to sustain life without catalysis. Enzyme kinetics gives biologists a quantitative language for describing how fast an enzyme works
Biology

Enzyme Kinetics and Metabolic Pathways

@openstem
Enzyme Kinetics and Metabolic Pathways
Note~1118 words · 6 min
Neurobiology: The Action Potential and Synaptic Transmission Neurons communicate using two linked electrical and chemical processes. Within a single neuron, information travels as an action potential — a stereotyped, self-propagating change
Biology

Neurobiology: The Action Potential and Synaptic Transmission

@openstem
Neurobiology: The Action Potential and Synaptic Transmission
Note~1203 words · 6 min
Developmental Biology: From Fertilization to Body Plan Developmental biology asks how a single fertilized egg, with no apparent structure beyond its own molecular contents, reliably builds a complex, patterned, multicellular organism. The a
Biology

Developmental Biology: From Fertilization to Body Plan

@openstem
Developmental Biology: From Fertilization to Body Plan
Note~781 words · 4 min
Animal Behavior and Ethology Ethology asks why animals behave as they do, treating behavior as a trait shaped by natural selection just like morphology or physiology. Behavior sits on a spectrum from rigidly innate to highly flexible and le
Biology

Animal Behavior and Ethology

@openstem
Animal Behavior and Ethology
Note~559 words · 3 min
Biogeography Biogeography asks why organisms are distributed across the globe as they are, and answers draw on both deep geological history — continents moving, seas rising and falling — and ongoing ecological processes of colonization and
Biology

Biogeography

@openstem
Biogeography
Note~598 words · 3 min
Biomechanics and Animal Locomotion Animal movement is governed by the same physics that governs any mechanical system: levers convert muscle force into limb motion, muscle itself has intrinsic force-generating limits that depend on both its
Biology

Biomechanics and Animal Locomotion

@openstem
Biomechanics and Animal Locomotion
Note~561 words · 3 min
Classical Genetics and Inheritance Patterns Mendel's laws of segregation and independent assortment describe the simplest possible inheritance case: one gene, two alleles, complete dominance, and genes on different chromosomes. Real inherit
Biology

Classical Genetics and Inheritance Patterns

@openstem
Classical Genetics and Inheritance Patterns
Note~596 words · 3 min
Comparative Vertebrate Anatomy Comparative anatomy asks how the same underlying structures have been modified across vertebrate lineages to serve different functions, and how convergent pressures have produced similar solutions from entirel
Biology

Comparative Vertebrate Anatomy

@openstem
Comparative Vertebrate Anatomy
Note~667 words · 3 min
Conservation Biology Conservation biology applies ecological and genetic theory to the practical problem of preventing extinction. Two threads run through the field: quantifying how and why small or declining populations are especially vuln
Biology

Conservation Biology

@openstem
Conservation Biology
Note~540 words · 3 min
Digestive Physiology Digestion breaks large, structurally complex macromolecules into small units simple enough to absorb, and does so through a tightly coordinated sequence: acid unfolds and begins digesting protein in the stomach, hormona
Biology

Digestive Physiology

@openstem
Digestive Physiology
Note~619 words · 3 min
DNA Repair Mechanisms DNA is under constant chemical and physical assault — spontaneous hydrolysis, oxidative damage from metabolism, UV radiation, replication errors — and cells maintain a suite of dedicated repair pathways, each specializ
Biology

DNA Repair Mechanisms

@openstem
DNA Repair Mechanisms
Note~566 words · 3 min
Enzyme Regulation and Allostery Metabolic flux must respond to a cell's changing needs on a timescale of seconds, far faster than gene expression can act. Allosteric regulation provides this speed: reversible, non-covalent binding of small-
Biology

Enzyme Regulation and Allostery

@openstem
Enzyme Regulation and Allostery

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