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Biology · L5 · Determining Structure, Then Quality-Controlling It: From Diffraction to Chaperone-Mediated Folding
How X-ray crystallography, cryo-EM, and solution NMR determine protein structure experimentally, how resolution is defined and interpreted per method, and how Hsp70/GroEL-GroES chaperones, the UPR, and prion misfolding govern folding fidelity in the cell.