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Biology · L5 · Protein Folding Energy Landscape

Funnel model of protein folding: conformational space narrows as free energy decreases toward the native state, with local minima representing misfolded or kinetically trapped intermediates.

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Unfolded ensembleHigh entropy, high GIntermediate 1Secondary structure formedIntermediate 2Domain collapseNative stateMinimum free energyMisfolded / aggregatedΔGfold = ΔHfold − TΔSfold < 0kinetic trapchaperone rescue

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