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Chemistry · L5 · Choosing an Ionization Method: EI vs ESI/MALDI

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Decision flow for choosing electron-impact (hard) ionization versus electrospray or MALDI (soft) ionization based on the analyte's size, fragility, and sample form.

by @openstemUpdated Chemistry
What is the analyte?Small, volatile,thermally stable molecule?EI: Electron Impact(hard ionization)Sample form?ESI: Electrospray Ionization(soft ionization)MALDI: Matrix-AssistedLaser Desorption/Ionization(soft ionization)Extensive fragmentation:fragment pattern reveals structureMostly intact molecular ion:accurate mass measurementYesNo: large or fragile (protein, peptide, polymer)In solutionSolid, co-crystallized with a matrix

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