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Biology · L5 · Nutrient-Sensing Longevity Network

How mTOR, AMPK, and sirtuin signaling integrate nutrient and energy status to shift cells between anabolic growth and stress-resistant longevity programs.

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Nutrient and Energy Status SensedHigh Nutrients Activate mTORC1Low Energy Activates AMPKHigh NAD Plus Activates SirtuinsAnabolism Favored Autophagy SuppressedCatabolism and Autophagy FavoredStress Resistance and Lifespan Extension

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