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Chemistry · L5 · Atropisomerism and Axial Chirality · flowchart

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by @openstemUpdated Chemistry
Biaryl with ortho substituentsHow bulky are the ortho groups?Rapid rotation: atropisomers interconvert fast, behave as one speciesSlow rotation: atropisomers configurationally stable, isolableCan be resolved into single enantiomersUsed as chiral catalyst or ligand scaffold, e.g. BINOL/BINAPSmall or absent: low barrierLarge, multiple: high barrier greater than 20-24 kcal/mol

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