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Biology · L5 · PINK1/Parkin Mitophagy Pathway

From loss of mitochondrial membrane potential through phospho-ubiquitin signal amplification to autophagosome-mediated clearance.

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Mitochondrion Loses Membrane PotentialPINK1 Import Blocked and Accumulates on Outer MembranePINK1 Phosphorylates UbiquitinParkin Recruited and ActivatedParkin Ubiquitinates Outer Membrane ProteinsAutophagy Receptors Bind Ubiquitin CoatDamaged Mitochondrion Engulfed by Autophagosome

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