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Biology · L5 · Central Tolerance: Thymic Selection

Decision path by which a developing thymocyte is either clonally deleted (negative selection) or matured into the peripheral repertoire (positive selection) based on the strength of self-antigen recognition.

by @openstemUpdated Biology
Developing T Cell in ThymusPresented Self-AntigensStrong Self-Reactivity DetectedNegative Selection ApoptosisWeak Self-Reactivity DetectedPositive Selection and Maturation

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