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Chemistry · L5 · The Kinetic Isotope Effect · flowchart

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by @openstemUpdated Chemistry
Proposed mechanism:is a specific C-H bond brokenin the rate-determining step?Synthesize the deuterium-labelledreactant: D substituted for Hat that exact positionRun the reaction with both thenormal (H) and labelled (D) reactant,measure rate constants kH and kDCalculate the ratio kH / kDIs kH/kD large(well above 1, typically 2-7)?Large kH/kD:strong evidence this C-H bondIS broken in the RDSkH/kD close to 1:this bond is NOT involvedin the rate-determining stepYesNo

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