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Biology · L5 · Hsp70 ATP-Dependent Chaperone Cycle

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How nucleotide state, J-domain co-chaperones, and nucleotide exchange factors regulate Hsp70 substrate binding and release.

by @openstemUpdated Biology
Hsp70 ATP Bound Low AffinityJ-Domain Co-Chaperone Delivers SubstrateATP Hydrolyzed to ADPHsp70 ADP Bound High Affinity Traps SubstrateNucleotide Exchange Factor Catalyzes ADP ReleaseATP Rebinds and Substrate Released

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