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Biology · L5 · Chaperone-Assisted Folding Pathway

Sequential path of a nascent polypeptide from ribosomal emergence through Hsp70 triage and the GroEL–GroES chaperonin chamber to a native or degraded fate.

Biology
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Nascent Polypeptide EmergesFrom RibosomeHsp70 Binds ExposedHydrophobic RegionsTransferred to GroEL-GroESChaperonin ChamberFolding Attemptin IsolationCorrectly FoldedProtein ReleasedMisfolded ProteinDegraded
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