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Chemistry · L5 · Host–Guest Selectivity Decision

Decision flowchart for predicting host–guest binding strength from cavity-to-guest size matching, using crown ether cation selectivity (18-crown-6 with K⁺, Na⁺, and Cs⁺) as the worked example.

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Crown ether host:fixed cavity diameterGuest cation sizevs cavity diameterSnug fit: all donor oxygenscontact guest simultaneouslyLoose fit: fewersimultaneous contactsCannot enter cavity:perches above the ringHigh association constante.g. 18-crown-6 with K⁺Low association constante.g. 18-crown-6 with Na⁺Low association constante.g. 18-crown-6 with Cs⁺Close matchGuest too smallGuest too large

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