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Biology · L5 · Eukaryotic Transcription Activation

Chromatin looping model linking an enhancer-bound transcription factor complex to the RNA Pol II pre-initiation complex at the core promoter via Mediator and cohesin.

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EnhancerH3K4me1 / H3K27acTF complexp300/CBP HATMediator complexCore promoterTSSH3K4me3RNA Pol IIPIC assemblyTranscription initiationTF bindingMediator bridgeCohesin-mediated loop

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