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Convergence of the Extrinsic and Intrinsic Coagulation Pathways

How tissue-factor-driven and contact-activated coagulation pathways both lead to fibrin clot formation via the common pathway.

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Vessel injury: tissue factor exposedExtrinsic pathway: factor VII activatedContact activation: factor XII activatedIntrinsic pathway: factors XI, IX, VIII activatedFactor X activatedProthrombin converted to thrombinFibrinogen converted to fibrin, cross-linked by factor XIIIStable clot forms

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