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Chemistry · L5 · Cytochrome P450 Catalytic Cycle

The full P450 cycle from substrate binding through O2 activation, Compound I formation, hydrogen-atom abstraction, and oxygen rebound.

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Resting Fe3+ heme, water boundSubstrate-bound Fe3+Fe2+ substrate complexFe2+-O2 oxy complexFe3+-peroxo intermediateCompound I: Fe4+=O porphyrin radical cationSubstrate radical, Fe4+-OHProduct R-OH releasedSubstrate binds, displaces waterFirst electron reductionO2 bindsSecond electron reductionProtonation, O-O heterolysis, water releasedHydrogen atom abstraction from substrateOxygen rebound

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