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Chemistry · L5 · Competitive vs Noncompetitive Enzyme Inhibition

Where an inhibitor binds — the active site versus an allosteric site elsewhere on the enzyme — determines whether it raises apparent Km (competitive) or lowers Vmax (noncompetitive).

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Enzyme with unbound active siteWhere does inhibitor I bind?Competitive inhibitionNoncompetitive inhibitionApparent Km increasesVmax unchanged: enough [S] still outcompetes IKm unchanged: I doesn't block S bindingVmax decreases: I compromises catalysis regardless of [S]Active site — I resembles SAllosteric site — separate from active site

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